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DEMO-PDL1-019 Design data

Sequence 61 aa

    1  MAVELKKLLE EAWKLLEEAP DGSAKELKKL LKEAKKLLGS GSWEYLKKLL EEAKLLLEEY
   61  K

Properties

Molecular weight7044.39
Theoretical pI6.89
Net charge at pH 7.4-0.06
GRAVY-0.461
Hydrophobic fraction0.459
Extinction coefficient (A280)13980
Cys count0

Developability warnings

  • Isomerisation @21 DG — Asp isomerisation — can cost binding
  • Oxidation @1 M — Met oxidation
  • Oxidation @13 W — Trp oxidation — can drive aggregation
  • Oxidation @43 W — Trp oxidation — can drive aggregation