PD-L1/Campaign/PDL1-R1 Pipeline

4 / 5 phases complete Read from what is actually in the database — runs, designs, filter verdicts, assay pages — not from the stage letter typed on the page.

A–C

Target prep

Done

PD-L1CD274 19-127PDB 4ZQK5 hotspots

The GFCC′ face of the IgV domain — the same front β-sheet PD-1 docks against, overlapping the atezolizumab/durvalumab epitope. Solvent-exposed, clear of the N-glycans, and clinically validated as a face whose blockade is functionally meaningful rather than just structurally occluding.

Open target

G–H

Triage

Done

bindcraft_default v124 → 66 shortlisted

Bottleneck: Complex pLDDT (16 cut)

See the cuts